ANTAGONISTSPRODUCEDBY A Streptomyces I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
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چکیده
New non-steroidal estrogen-receptor antagonists, R1 128 A, B, C and D, were isolated from the cultured broth of Streptomyces sp. No. 1 128 by solvent extraction, silica gel chromatography, reverse phase chromatography and preparative HPLC. These compounds inhibited estrogen binding to its receptor. The IC50 values of R1 128 A, B, C and D for partially purified rat uterine cytosol receptor were 1.1 x 10~7m, 1.2 x 10~7m, 2.6x 10~7Mand2.7 x 10~7m, resDectivelv.
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